Association of Dyslipidemia and Inflammatory Markers in Type 2 Diabetes Mellitus

Background: The interplay between inflammation and lipids has recently been the focus of research aimed at understanding the development of Type 2 diabetes mellitus and the process of atherogenesis. Inflammatory markers particularly Tumor necrosis factor-α and high sensitive C-reactive protein interfere with lipid homeostasis and activates proinflammatory mechanisms in type-2 Diabetes mellitus. Our aim of the study was to analyze and correlate the inflammatory markers with lipids in Type2 Diabetes mellitus. 50 diabetic subjects and 50 normal healthy controls were recruited from the outpatient department of Narayana Medical college and hospital, Nellore, A.P). Serum TNF-alpha concentration was measured using Sandwich ELISA kit method. commercial enzymatic methods were used in the determination of serum total.cholesterol, HDL cholesterol and Triacylglycerides. LDL cholesterol was estimated using friedewald equation. Turbidimetric immunoassay (QUANTIA CRPUS) is used for ultrasensitive determination of high sensitive C-reactive protein in serum. Results: serum levels of TNF-α and hs-CRP were significantly elevated in type 2 diabetes mellitus and correlated positively with triacylglycerides, total cholesterol and LDL cholesterol but negatively with HDL cholesterol. We conclude from our study that there is a strong association between proathergenic lipid profile and inflammatory markers in Type2Diabetes mellitus and suggests a significant role of the inflammatory markers in the pathogenesis of dyslipidemia in Type2diabetes mellitus.